Supporting people in hospitals across South Australia through vital health and medical research and improved patient care.
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Supports research into the detection, management & treatment of breast cancer.
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Our aim is to reduce & eliminate the high incidence of chronic kidney disease and diabetes.
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Supporting world-class stroke research to improve prevention, diagnosis & acute treatment to cure stroke.
Providing donor stool to treat patients with bowel conditions and foster research into faecal transplant as a treatment.
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Adelaide researchers from the Centre for Cancer Biology (CCB) have discovered for the first time a protein previously linked to controlling blood pressure also prevents salt-induced kidney disease.
Leading this potentially life-changing research is Professor Sharad Kumar with Research Fellows Dr Jantina Manning and Dr Tanya Henshall who are hoping their discovery could lead to a new way of targeting kidney disease to prevent it from affecting more Australians in the future.
“We have identified a protein that protects the kidneys against salt-induced kidney damage. It does this by controlling the activity of a channel through which salt re-enters the blood stream following filtration by kidney,” Tanya explains.
“We discovered that when this protein is not present there is a greater amount of this channel which ultimately means more salt is entering into the body and this leads to kidney disease,” she added.
“If we block this channel with medication, we can in fact reduce the likelihood of kidney damage.”
High salt consumption is common in a modern diet, and with the knowledge that this could give rise to kidney damage, Tanya and Jantina are now working to better understand this protein and how it could be targeted to prevent kidney damage from occurring.
“It may not be that a person is missing this protein, but rather has a mutation in it that means it’s not functioning properly. There is evidence that mutations in this protein relate to hypertension, and we now think that such mutations may also be contributing to kidney damage in some patients. By targeting this protein and its downstream events, we could treat the kidney damage in these patients,” Jantina said.
Knowing that 1 in 10 people currently have chronic kidney disease, with many unaware they are living with it, this discovery could improve outcomes for many living with the debilitating disease in the future.
“This discovery really opens up so many more avenues for further research in the fight for a cure for kidney disease,” Tanya said.
“Whilst we are in the early stages of this work, there are options for treatments in the future, including looking at avenues of using drugs that are already out there,” Jantina said.
“There is also the potential for the development of new medications in the future once we better understand the mechanisms involved,” Tanya added.
With current kidney disease patients only having dialysis or a transplant available to them, this innovative research could open up a new treatment and ultimately save more lives from this debilitating disease.
Please donate to the Centre for Cancer Biology and support groundbreaking research like this.
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This year, we’re celebrating a major milestone – 50 years of kidney transplants in Australia, beginning at The Queen Elizabeth Hospital (TQEH).
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PhD student Zaipul Md Dom and the Department of Clinical Pharmacology at TQEH and the Basil Hetzel Institute for Translational Health Research, are undertaking research which will potentially mean more people can have successful kidney transplants without negative side effects. read more
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Fay has been a THRF Life Guardian for almost 20 years and hopes her support will help find a treatment for kidney disease which has plagued several members of her family. read more
Kidney Health Awareness Week occurs from May 26th to June 1st . Your kidneys are vital organs, and it’s important to keep them healthy. Maintaining a healthy weight through both regular exercise and a healthy diet will help. read more
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Thanks to our generous community, The Hospital Research Foundation (THRF) supports lifesaving research that will see new and improved treatments for common diseases reach our community sooner.
Just recently THRF directed $75,000 in funding to Dr Natasha Harvey and her world-class team at the Centre for Cancer Biology (CCB) to support their vital work into halting the spread of common cancers and the condition of lymphoedema. read more
Head of the Cell Signalling Laboratory at the Centre for Cancer Biology (CCB), Associate Professor Yeesim Khew-Goodall is leading a crucial research project focused on overcoming resistance to cancer therapy, particularly in triple negative breast cancer. read more
An exciting study is underway that could potentially lead to new treatments for metastatic prostate cancer (cancer that spreads around the body) at the Centre for Cancer Biology (CCB). read more
At the young age of four months, Robert Kenrick’s daughter Martha was diagnosed with eczema. For Robert, this meant rubbing his daughter’s back for almost an hour at night to help her get to sleep because her skin was so itchy. It meant seeing her fall behind in school as she wasn’t getting the amount of sleep a young child needs. read more
Leading cutting-edge research into inflammation in a variety of cancers, Professor Vinay Tergaonkar from Singapore’s Agency for Science Technology and Research (A*Star) joined the Centre for Cancer Biology (CCB) in 2016, a unique new research laboratory collaboration. read more
World-class research at the Centre for Cancer Biology (CCB) in Adelaide is aimed at developing new treatments and preventing some of the most common and heartbreaking cancers affecting your loved ones. read more